Does Microvolt T-Wave Alternans Testing Predict Ventricular Tachyarrhythmias in Patients With Ischemic Cardiomyopathy and Prophylactic Defibrillators?
نویسنده
چکیده
Methods This prospective trial was conducted at 50 U.S. centers. Patients were eligible if they met MADIT-II (Multicenter Automatic Defibrillator Implantation Trial II) indications for device implant. All patients underwent MTWA testing followed by ICD implantation, with pre-specified programming to minimize the likelihood of therapies for non–life-threatening VTE. Minimum follow-up was 2 years with annual MTWA testing. Initially indeterminate MTWA tests were repeated.
منابع مشابه
Multiple autonomic and repolarization investigation of sudden cardiac death in dilated cardiomyopathy and controls.
BACKGROUND Prophylactic defibrillator implantation is recommended in dilated, nonischemic heart disease and left ventricular ejection fraction of ≤0.30 to 0.35. Noninvasive testing should improve accuracy in decision making of prophylactic defibrillator implantation. METHODS AND RESULTS We enrolled 60 patients (median age, 57 years) with dilated cardiomyopathy and left ventricular ejection fr...
متن کاملImmediate ventricular tachycardia after abnormal microvolt T-wave alternans.
Microvolt T-wave alternans (MTWA) is a promising non-invasive method of evaluating repolarization abnormalities. Its presence is strongly related to the occurrence of malignant ventricular tachyarrhythmias and is therefore regarded as a risk marker for sudden cardiac death. Most recent studies have described the usefulness of MTWA in selecting patients who may benefit from a cardioverter-defibr...
متن کاملT-wave alternans and sudden cardiac death.
Sudden cardiac death (SCD) is the leading cause of mortality in patients with ischemic heart disease and left ventricular dysfunction. The majority of SCD are due to ventricular tachyarrhythmias. SCD strikes many asymptomatic patients and often is the first manifestation of heart disease. Thus, reliable determination of arrhythmic risk is warranted to guide preventive therapy. To highlight the ...
متن کاملNoninvasive arrhythmia risk stratification in idiopathic dilated cardiomyopathy: results of the Marburg Cardiomyopathy Study.
BACKGROUND Arrhythmia risk stratification with regard to prophylactic implantable cardioverter-defibrillator therapy is a completely unsolved issue in idiopathic dilated cardiomyopathy (IDC). METHODS AND RESULTS Arrhythmia risk stratification was performed prospectively in 343 patients with IDC, including analysis of left ventricular (LV) ejection fraction and size by echocardiography, signal...
متن کاملUsefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational study.
OBJECTIVES This study was designed to evaluate the ability of microvolt-level T-wave alternans (MTWA) to identify prospectively patients with idiopathic dilated cardiomyopathy (DCM) at risk of ventricular tachyarrhythmic events and to compare its predictive accuracy with that of conventional risk stratifiers. BACKGROUND Patients with DCM are at increased risk of sudden death from ventricular ...
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